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Edifier MR4 Powered Studio Monitor 2.0 Speakers 42 Watts (Black)

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Right out of the gate, I didn’t have great expectations in regard to the bass performance out of such small woofers; you can only bend the laws of physics so far and even with the bass ports — my expectations were that the bass performance would almost demand the addition of a subwoofer. Utilising 1-inch silk dome tweeters to produce a smooth and high-frequency sound, and the special coating added on it ensures a more natural and refined treble. With techno/drum loop content such as Peace of Mind track you see in the EQ panel, it could get quite a bit louder with no audible distortion. For the analysis of survival from CML-related deaths (CML-OS), patients dying from any cause other than CML progression were censored at the date of death; all the other subjects were censored at the date of last follow up. Based on the accurate analysis of the characteristics of the unit by the German KLIPPEL system, a flatter curve necessary for a monitor is acquired after dozens of professional tunings by Edifier Acoustic Lab.

at 5 years) and the potential to subsequently lose CCyR, would favor continuation of molecular monitoring at a minimum frequency of 3-monthly in this group. Achieving a major molecular response at the time of a complete cytogenetic response (CCgR) predicts a better duration of CCgR in imatinib-treated chronic myeloid leukemia patients. Sharing published material for non-commercial purposes is subject to the following conditions: https://creativecommons. Simone Claudiani, Aoife Gatenby, Richard Szydlo, George Nesr, Adi Shacham Abulafia, Renuka Palanicawandar, Georgios Nteliopoulos, Jamshid Khorashad, Letizia Foroni, Jane F.In using a ‘real-life’ patient cohort, we appreciate that there are complexities of decision-making that are confounding compared to the rigorous clinical trial environment. The pandemic changed all of that for a lot of people who suddenly had the urge and desire to use loudspeakers in their home office. Patients who achieved sMR3 after an increase in the dose of imatinib were more likely to lose MR3 than patients who achieved sMR3 after a change to a 2GTKI ( Online Supplementary Table S2). Overall survival (OS) and the event-free survival (EFS) were estimated using the Kaplan-Meier method. For those of you interested to know, if you plug an RCA cable into say one of your two PC monitors and then plug an aux cable into the other, they both output audio at the same time.

The sub-bass is rolled-off below 80Hz and the impact is limited, but the bass was surprisingly well controlled and cleaner than I had expected.At least three consecutive assessments, at a frequency of 3-4 monthly, were required to define sustained response.

However, for only a few dollars more, the Neumi BS5P includes digital inputs and measures better, but seems to have noticeably less bass output. My listening sessions started with my digital sources at 100% output and I used the MR4’s volume knob to control the overall system volume; as long as I stayed below 75% on the volume control, music was very transparent throughout the bass and midrange. The majority of patients with newly diagnosed chronic myeloid leukemia (CML) will enjoy a life expectancy equivalent to that of unaffected individuals, but will remain on life-long treatment with a concomitant requirement for on-going hospital interactions for molecular monitoring and drug dispensing.The views expressed in this article are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health. Deescalation of tyrosine kinase inhibitor dose in patients with chronic myeloid leukaemia with stable major molecular response (DESTINY): an interim analysis of a non-randomised, phase 2 trial. A Suitably Near-flat Response: Professionally fine-tuned to an appropriately neutral, flat response to naturally present the sound of the recording/mix-in-progress, which improves the accuracy of recording levels, mic placement, mix balance, EQ, mastering processing, etc. The median number of RT-qPCR assays in the first year of MR4 was four (range: 3-11), with a median interval among samples of 2. Assessment of BCR-ABL1 transcript levels at 3 months is the only requirement for pre dicting outcome for patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors.

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